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Kreb's cycle-something we hear about alot, a little hard to understand. (citation below)

June 13th, 2009 by Lynnette Marshall

The Krebs cycle is the first of two stages of a process called cellular respiration, in which glucose is transformed into a usable form of chemical energy called adenosine triphosphate, or ATP. Although cellular respiration is a relatively complicated process, involving dozens of steps, its chemical equation is quite simple. It begins with the raw materials glucose and oxygen and yields carbon dioxide and water (both waste products) and free energy, some of which is captured and stored in usable form as ATP. The chemical equation for this conversion is C6H12O6 + 6 O2 ---> 6 CO2 + 6 H2O + energy (ATP).

This process cannot begin without glucose, a simple sugar molecule made up of 6 atoms each of carbon and oxygen and 12 atoms of hydrogen. However, all of us consume many types of food besides glucose. In fact, glucose is relatively uncommon in our diets. Over the course of a typical day, most people consume a combination of carbohydrates, fats, and proteins. So where does the glucose required to power cellular respiration come from?

The food we eat must be broken down before it ever enters the cell's mitochondria, where cellular respiration takes place. Breaking down complex carbohydrates into glucose is a relatively simple process. Complex carbohydrate molecules are made up primarily of multiple glucose molecules linked together. Enzymes in the stomach and intestines separate individual glucose molecules from one another early in the digestive process. In contrast, fats and amino acids, the molecules that make up proteins, have chemical structures that only vaguely resemble glucose. They contain carbon, hydrogen, and oxygen atoms, just like glucose, but in dramatically different ratios.

The liver is responsible for converting these molecules into glucose. It is also the place where excess carbohydrates are converted into a readily available but storable carbohydrate molecule called glycogen and into fat. The direction of these conversions depends on the level of glucose in the blood. When the concentration of glucose in the blood is low, the liver converts glycogen and fat (and in their absence, protein) into glucose. When blood glucose levels are high, the liver reverses the process, storing carbohydrates and maintaining fat and protein stores.

Cells obtain glucose from the blood, through the walls of capillaries nearby. These capillaries carry not only glucose but also oxygen and many other important nutrients. Once inside the cell glucose is absorbed by organelles called mitochondria. These important structures play host to the two stages of cellular respiration: the Krebs cycle and the electron transport chain. Combined, these chemical conversions and the raw material glucose that feeds them, produce the energy that drives nearly every cellular process in your body.

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  • Lynnette

    I'm going to add some comments that go along with this. To view how darn complicated this is go to this->

    en.wikipedia.org/wiki/Krebs_cycle   I don't know if that will show up as a link or just an address. 

    One reason finding a simple answer for those of us w/ Fibromyalgia and CFS is so hard is that about 1/2 the researcher's believe the problem starts in this kreb's cycle. This reaction goes on repeatedly in your body. It produces ATP, which basically is your energy.

    The words to remember here are- ATP, Lactic acid, and glucose. These are buzzwords to people who market the supplements that are pitched to us.

    32 months ago

  • Lynnette

    The Krebs cycle refers specifically to a complex series of chemical reactions in all cells that utilize oxygen as part of their respiration process. This includes those cells of creatures from the higher animal kingdom, such as humans. The Krebs cycle produces carbon dioxide and a compound rich in energy, Adenosine triphosphate (ATP). This chemical provides cells with the energy required for the synthesis of proteins from amino acids and the replication of deoxyribonucleic acid (DNA).

    Within the Krebs cycle, energy in the form of ATP is usually derived from the breakdown of glucose, although fats and proteins can also be utilized as energy sources. Since glucose can pass through cell membranes, it transports energy from one part of the body to another.

    http://www.wisegeek.com/what-is-the-krebs-cycle.htm

    OK- this is where all the info from diets and supplements comes in. For instance-you want to go on a low carb diet- look at the second paragraph-energy comes from the breakdown of glucose, and in the absence of glucose(carbs) protein and fats can be used. The idea of atkins diet, for instance, is to force the body to use fats for energy. In the presence of starvation the body will use protein (that is your muscles and you don't want this). 

    Is this stuff helping? Don't be discouraged if the krebs cycle is very hard to get. It's been the most dreaded test question for Doctors and nurses forever. Please let me know what things you would like to learn that a nurse could teach you.

    32 months ago

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